| HyTEC 2111 - Head and Neck Tumor Control Probability: Radiation DoseeVolume Effects in Stereotactic Body Radiation Therapy for Locally Recurrent Previously-Irradiated Head and Neck Cancer: Report of the AAPM Working Group (2018) Category: HyTEC In a systematic review of the available literature addressing the dose/volume data for tumor control probability with SBRT in patients with locally recurrent previouslyirradiated head and neck cancer, data from more than 300 cases in 8 publications suggest that there is a doseeresponse relationship with superior local control and possibly improved overall survival, for doses of 35 to 45 Gy (in 5 fractions) compared with <30 Gy. Stereotactic body radiation therapy doses equivalent to 5 fraction doses of 40 to 50 Gy are suggested for retreatment. International Journal of Radiation Oncology*Biology*Physics https://doi.org/10.1016/j.ijrobp.2018.01.044 John A. Vargo, MD, Vitali Moiseenko, PhD, Jimm Grimm, PhD, Jimmy Caudell, MD, David A. Clump, MD, PhD, Ellen Yorke, PhD, Jinyu Xue, PhD, Yevgeniy Vinogradskiy, PhD, Eduardo G. Moros, PhD, Panayiotis Mavroidis, PhD, Sheena Jain, MD, Issam El Naqa, PhD, Lawrence B. Marks, MD, and Dwight E. Heron, MD, MBA, FACRO, FACR |
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