| HyTEC 2107 - Single- and Multi-Fraction Stereotactic
Radiosurgery Dose Tolerances of the Optic
Pathways (2018) Category: HyTEC Data were pooled from published reports to analyze dosimetric and clinical predictors of radiation-induced optic neuropathy [?] (RION) after stereotactic radiosurgery in 1-5 fractions. Risks of RION are low (<1%) in the modern era with optic apparatus maximum point doses of <10 Gy in 1 fraction, 20 Gy in 3 fractions, and 25 Gy in 5 fractions (in patients without prior radiation therapy). More standardized dosimetric and toxicity reporting is needed to facilitate future pooled analyses and better define RION normal tissue complication probability (NTCP). Supplemental Materials 1 International Journal of Radiation Oncology*Biology*Physics https://doi.org/10.1016/j.ijrobp.2018.01.053 Michael T. Milano, MD, PhD, Jimm Grimm, PhD, Scott G. Soltys, MD, Ellen Yorke, PhD, Vitali Moiseenko, PhD, Wolfgang A. Tomé, PhD, Arjun Sahgal, MD, Jinyu Xue, PhD, Lijun Ma, PhD, Timothy D. Solberg, PhD, John P. Kirkpatrick, MD, PhD, Louis S. Constine, MD, John C. Flickinger, MD, Lawrence B. Marks, MD, and Issam El Naqa, PhD |
DISCLAIMER