Encrypted | Login

AAPM has contracted with NCRP to provide each AAPM Member in good standing access and download privileges of electronically available NCRP reports, commentaries and statements. This report was prepared by the National Council on Radiation Protection and Measurements (NCRP). The Council strives to provide accurate, complete and useful information in its reports. However, neither the NCRP, the members of NCRP, other persons contributing to or assisting in the preparation of this report, nor any person acting on the behalf of any of these parties (a) makes any warranty or representation, express or implied, with respect to the accuracy, completeness or usefulness of the information contained in this report, or that the use of any information, method or process disclosed in this report may not infringe on privately owned rights; or (b) assumes any liability with respect to the use of, or for damages resulting from the use of, any information, method or process disclosed in this report.

Commentary No. 031 - Development of Kinetic and Anatomical Models for Brain Dosimetry for Internally Deposited Radionuclides (2022) This is a members only link.

Price: $55 PDF (AAPM Members FREE)
Category: Commentary

This Commentary examines current information on the accumulation, distribution, and retention of radionuclides in the brain and the extent to which that information can be used to improve estimates of dose to potentially radiosensitive regions of the brain from internal emitters, with emphasis on high linear-energy transfer alpha particle-emitting radionuclides. Dose estimates for the brain based on explicit brain models reflecting best available biokinetic data are compared with estimates based on the brain models typically used in radiation protection and dose reconstruction. The comparisons indicate that predictions of brain doses based on current models for radionuclides may substantially underestimate or overestimate brain dose projections based on an explicit brain model reflecting best available biokinetic data. Potential improvements in dose estimates for the brain based on more detailed dosimetric models of the brain are also examined. Improved estimates of radiation doses to brain based on more realistic biokinetic and dosimetric representations of the brain would be an important step forward in ongoing epidemiologic research aimed at evaluating dementia, Alzheimerís, Parkinsonís, motor neuron diseases and cognitive impairment as possible adverse effects of radionuclide depositions in the brain.

Scientific Committee :

  • Richard W. Leggett, Chair
  • Sergei Y. Tolmachev, Vice Chair
  • Maia Avtandilashvili
  • Keith F. Eckerman
  • George Sgouros
  • Gayle E. Woloschak
  • Helen A. Grogan, Staff Consultant

I Disagree
I Agree

Show list of all NCRP documents »