Program Information
Exploiting the Lanthanide Doped Manganese Oxide Based Theranostic Nanoparticles for Cancer Radiation Therapy
R Mangaiyarkarasi, S Bastani, J Cho* Oklahoma State University, Stillwater, OK
Presentations
TU-C2-GePD-JT-2 (Tuesday, August 1, 2017) 10:00 AM - 10:30 AM Room: Joint Imaging-Therapy ePoster Theater
Purpose: To quantify the effect of Lanthanidedoped Mn2O3nanoparticles for improving the efficacy of radiation therapy. Despite extensive research on gold nanoparticles (GNPs) as radiosensitizers, their limited in vivo imaging capability hampers their transition from bench top to bedside. In this research, we synthesized Eu-doped Mn2O3 nanoparticles as possible MR visible radiosensitizers.
Methods: First, Manganese oxide(Mn2O3) nanoparticles was synthesized using chemical precipitation method as follows. 1:2 ratio of manganese chloride and sodium hydroxide were dissolved in 50mL of deionised water which was kept under vigorous stirring for 2 hrs at 60°C. Meanwhile, 0.1mg/mL of polyethylene glycol was added to avoid unwanted agglomeration of nanoparticles. The product was collected after filtration was washed with DI water for several times and allow it to dried for 18hrs at 70°C in air. The Mn2O3 nanoparticles thus prepared was stored at room temperature (25°C).For the preparation of Eu- doped Mn2O3 nanoparticles, 0.5mg of Mn2O3 diluted in 10 mL of ethanol were dispersed in 0.05mg of europium nitrate dissolved in 50mL of DI water and stirred under RT for 2 hrs. The resultant solution was then centrifuged, washed thrice and stored in DI water for further investigations.
Results: The fluorescence excitation and emission spectrum of Eu - doped nanoparticles were recorded using Fluorolog-3 and it was observed that there is a presence of excitation maxima at 394 nm and emission maxima at 590 nm respectively. This indicates that there may be an occurrence of europium element on the surface of Mn2O3 nanoparticles. Usually, magnetic nanoparticles and metal oxide nanoparticles may not produce any emission spectrum as it has no fluorescence property.
Conclusion: The characterization shows the successful synthesis of Eu-doped Mn2O3 nanoparticles. The future study will investigate their radiosensitizing effect in comparison with GNPs and MR visibility.
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