Program Information
Novel Radiopaque Bismuth Nanoparticle Coated Polydioxanone and Comparison of Attenuation in Pre-Clinical and Clinical CTs
L Tian1 , L Lu2 , B Singhana3 , M Jacobsen4 , A Melancon5 , M Melancon6*, (1) The University of Texas MD Anderson Cancer Center, Houston, TX, (2) University of Texas M D Anderson Cancer Center, Houston, TX, (3) The University of Texas MD Anderson Cancer Center, Houston, TX, (4) UT MD Anderson Cancer Center, Houston, TX, (5) University of Texas MD Anderson Cancer Center, Houston, TX, (6) MD Anderson Cancer Center, Houston, TX
Presentations
SU-I-GPD-J-91 (Sunday, July 30, 2017) 3:00 PM - 6:00 PM Room: Exhibit Hall
Purpose: To develop a bismuth nanoparticle (BiNP)-coated polydioxanone (PPDO) and to compare the visualization of this novel radiopaque material for both pre-clinical and clinical CT scanners.
Methods: Novel radiopaque PPDO were prepared by coating with BiNP. Preparation, characterization and cytotoxicity evaluation were performed according to published protocols. Radiopacity was evaluated on three CT scanners, including a GE CT-eXplore Locus RS preclinical in vivo scanner (micro-CT), a GE HiSpeed Advantage helical scanner (conventional CT), and a Siemens Somatom Definition Flash DECT.
Results: BiNP particle size was 40 – 1000 nm. SEM clearly showed BiNP coating on PPDO sutures. Some cytotoxicity was observed on Panc1 cells. BiNP significantly improved radiopacity of PPDO sutures on all three CT scanners. HU values calculated from micro-CT was 1068 for BiNP-coated PPDO versus 28 ± 6 for control PPDO. Conventional CT showed 152 ± 191 for coated, while control had -520 ± 65. DECT values was 178 for coated versus -475 ± 23 control. Micro-CT clearly had higher resolution than clinical CT, and also yielded higher Hounsfield unit (HU) values. The reason for lower HU values on the clinical CT could be caused by averaging air signal (HU -1000) into the suture due to the lower resolution and partial voluming.
Conclusion: Radiopaque BiNP-PPDO was successfully developed and BiNP coating significantly increased HU values of PPDO on pre-clinical and clinical CT scanners. This study is the first step towards developing totally absorbable medical device inexpensively deployed and monitored by conventional imaging methods that prevents pulmonary embolism for the recommended prophylactic period and then simply vanishes without intervention. Successful development of imaging enhancers for IVC filters may also lead to widespread use of absorbable devices in other cardiovascular and orthopedic applications in which fixtures (such as plates, screws, nails, and rods) are needed only on a temporary basis.
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