Program Information
Association of MRI Radiomics Feature Changes with Treatment Outcome for Radiotherapy of Nasopharyngeal Carcinoma
Y TAO1*, X Chen2 , X Yang3 , X Deng4 , Y XIA5 , X Li6 , (1) Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, (2) Medical College of Wisconsin, Milwaukee, WI, (3) Sun Yat-Sen University Cancer Center (SYSUCC), Guangzhou City, Guangdong Prov., (4) Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, (5) Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, (6) Medical College of Wisconsin, Milwaukee, WI
Presentations
WE-F-205-7 (Wednesday, August 2, 2017) 1:45 PM - 3:45 PM Room: 205
Purpose: To analyze the radiomics feature changes of gross tumor volume (GTV) and parotid glands (PG) in MRI acquired before and after chemoradiation therapy (CRT) for nasopharyngeal carcinoma (NPC) and their correlations with clinical outcomes.
Methods: T2-weighted MRI acquired using a MR simulator for 10 NPC patients before and after CRT was quantitatively analyzed. The GTV and PG were delineated consistently using MIM software on each MRI set. Six intensity histogram based radiomic metrics, including mean intensity, volume, standard deviation (SD), skewness, kurtosis, and entropy were calculated in GTV and PG from each MRI set. Correlations between the changes of these features before and after CRT in GTV, the tumor responses, and blood test results, and between the PG feature changes and the observed acute xerostomia were analyzed. The significances were inspected using student’s t-test and the correlations were analyzed using Spearman and Pearson correlation tests.
Results: Changes in various PG radiomic metrics before and after CRT were observed. Average PG volume reduction was 5.5cm3±1.6cm3. The increase in SD was 34.4±8.1 HU for ipsilateral PG, which was significantly greater than the contralateral PG, 22.9±11.7 HU (p=0.0007). This difference was due to the factor that the doses to ipsilateral PG were generally higher than those to contralateral PG. The average change of SD of both PGs were strongly correlated with the observed xerostomia grades (coefficient =0.75, p=0.012). Average reduction of GTV were 17.20cm3±15.45cm3 (range:4.90-52.99 cm3). The correlation between the changes of GTV entropy before and after CRT and tumor response has a coefficient of 0.59 (p=0.07).
Conclusion: Significant changes in the T2 intensity histogram radiomic metrics of the GTV and parotid glands were observed before and after CRT for NPC. These changes may be used to predict tumor and/or normal tissue treatment responses.
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