Program Information
Use of 3D-Printed Patient Specific Neurovascular Phantoms to Assess Performance of Basis Material Decomposition On Images Acquired Using a CMOS-Based Micro-CBCT System
A Podgorsak1, 2*, A Venkataraman1, 2 , S Setlur Nagesh1 , D Bednarek1 , S Rudin1, 2 , C Ionita1, 2 , (1) Toshiba Stroke and Vascular Research Center, Buffalo, New York, (2) Department of Biomedical Engineering, University at Buffalo, Buffalo, New York
Presentations
SU-K-702-3 (Sunday, July 30, 2017) 4:00 PM - 6:00 PM Room: 702
Purpose: To assess the performance of basis material decomposition using dual-energy micro-CBCT images taken of a 3D-printed patient specific neurovascular phantom with different interventions performed on them.
Methods: An aneurysm model was 3D-printed and two neurovascular interventions were performed on it. A platinum coil was deployed into the aneurysm sac, and a cobalt-chromium (CoCr) stent was placed to span the aneurysm orifice. Imaging of the model was performed with a CMOS-based micro-CBCT system using dual-energy (DE) acquisitions done for tube voltages of 35 and 70 kVp. Axial slices of the model were computed using the FDK algorithm. Basis material decomposition was performed using the reconstructed DE image data, considering the platinum and CoCr as basis materials for decomposition. An additional trial was carried out following addition of iodine contrast agent to the model, considering the platinum, CoCr, and iodine as basis materials for decomposition. X-ray tube and reconstruction parameters were kept constant throughout.
Results: Examination of the output basis material slices from the first intervention indicates that the algorithm was able to decompose between the platinum and CoCr. When a slice with just the platinum coil and CoCr stent was present, the decomposition was carried out with minimal error. With the addition of the iodine contrast, the decomposition between the platinum and CoCr was still apparent. When a slice devoid of platinum, and with the CoCr stent and iodine contrast present was considered, the decomposition between the CoCr and iodine was accurate and the platinum map correctly displayed no material.
Conclusion: This work indicates the potential clinical utility of basis material decomposition in the neurovascular anatomical region of the body, as well as the potential for using this method on pre-clinical images acquired using a CMOS-based micro-CT system.
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