Program Information
Dosimetric Advantages of Carbon Ion Therapy Over Proton and Photon Therapy for Hyper-Fractionated Hepatocellular Carcinoma (HCC) Patients
w wang*, J SUN , Y Sheng , K Shahnazi , G Jiang , Shanghai proton and heavy ion center, Shanghai, shanghai
Presentations
SU-I-GPD-T-165 (Sunday, July 30, 2017) 3:00 PM - 6:00 PM Room: Exhibit Hall
Purpose: to identify the dosimetric benefits of carbon ion therapy compared to proton and photon therapy for HCC patients.
Methods: eight HCC patients were involved, the internal target volumes (ITVs) were far away from gastrointestinal tracts. 65GyE/10Fx was delivered to ITV. By using the breath control techniques, the movements of livers were controlled less than 5 mm in all directions. For the individual plans, two or three raster-scanning proton beams or carbon ion beams were used, and photon intensity modulated radiotherapy (IMRT) with five beams were used. The expected mean dose to liver minus gross tumor volume (liver-GTV) and right kidney was less 15 GyE and 10 GyE.
Results: the dose coverages of 95% of prescription (V95) to the ITVs were comparable, which were 99.6±4.8%, 99.9±3.7%, 99.8±3.2% (median ± SD) for proton, carbon ion and photon respectively. The live-GTV mean doses delivered by carbon ion (15.49 ± 2.62 GyE) were better than dose delivered by proton (17.00 ± 2.92 GyE) and photon (23.17 ± 4.30 GyE). This was also true for right kidney mean doses (photon: 5.91±10.70 GyE VS proton: 2.84±8.46 GyE VS carbon ion: 2.00±9.41 GyE). However, the stomach maximum doses from proton beams (2.61 ± 13.55 GyE) were relatively lower than dose from carbon ion (10.03 ± 12.79 GyE) and photon beams (29.92 ± 7.10 GyE).
Conclusion: by using carbon ion therapy, HCC patients can gain more dosimetric benefits to the organ at risks while maintaining the comparable dose coverage.
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