Program Information
Tomographic Reconstruction From Limited-Angle Digital Breast Tomosynthesis
G Ge1*, Q Yang2 , X Wang3 , G Wang4 , J Zhang5 , (1) VA Lexington Hospital, Lexington, KY, (2) Rensselaer Polytechnic Institute, Troy, NY, (3) University of Kentucky, Lexington, KY, (4) Rensselaer Polytechnic Institute, Troy, NY, (5) University of Kentucky, Lexington, KY
Presentations
TU-C1-GePD-I-5 (Tuesday, August 1, 2017) 9:30 AM - 10:00 AM Room: Imaging ePoster Lounge
Purpose: Achieving negative margins during breast conserving surgery is critical as it is an important prognostic factor. To this date, intraoperative evaluation of breast tumor margins still heavily depends on two-dimensional radiography, which cannot clearly discern residual disease at the margins. This study is to develop a novel tomographic technique to reconstruct 3D transverse images from limited-angle tomosynthesis projections for better margin visualization.
Methods: A mathematical breast tumor phantom was developed based on X-ray attenuation values from National Institute of Standards and Technology (NIST) at 28 kV. Projections were generated according to the Hologic Digital Breast Tomosynthesis (DBT) system, in which the X-ray tube rotates approximately from -7.5 to 7.5 degrees, with 15 projections for each acquisition. Two acquisition configurations were proposed, one with two DBT acquisitions from two-view angles, 0 and 90 degrees, while another used three DBT acquisitions from three-view angles, -60, 0, and 60 degrees. Tomographic 3D images were reconstructed using a newly-developed SART-TV algorithm.
Results: The attenuation values of adipose, breast, soft tissues are 0.341/cm, 0.418/cm, and 0.496/cm, respectively. Calcification-mimicking aluminum is 4.29/cm. The tumor size for the simulation is roughly 4 cm with calcification less than 100 micrometers. The contrast is 13.6% between adipose and breast tissue, 23.5% between breast and soft tissue, and 8.6% between adipose and soft tissue for two-view configuration, while the corresponding contrast for three-view configuration is 13.6%, 26.3%, and 11.8%. The contrast differences can be visually distinguished. The three-view angle configuration provides clearer images than the two-view angle configuration, indicating that there may be an optimized acquisition configuration with minimal projections.
Conclusion: The proposed imaging technique is unique in providing more detailed tomographic images showing tumor margins than 2D mammography and quasi-3D DBT. This imaging technique can be readily applied to any DBT system with no requirement for hardware update.
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