Program Information
The Concept of Therapeutic Efficiency and Its Application in the Evaluation of HCC SBRT Treatment
M Cheung1,2*, D Poon2 , V Yeung2 , L Lee2 , A Chan1,2 , (1) The Chinese University of Hong Kong, Hong Kong, (2) Prince of Wales Hospital, Hong Kong,
Presentations
SU-I-GPD-T-523 (Sunday, July 30, 2017) 3:00 PM - 6:00 PM Room: Exhibit Hall
Purpose: To evaluate hepatocellular carcinoma (HCC) SBRT treatment in Prince of Wales Hospital in terms of therapeutic gain.
Methods: A logistic model of the TCP of HCC and the corresponding NTCP of normal liver (liver minus gross tumour) were fitted with clinical data of 30 SBRT HCC patients treated in Prince of Wales Hospital using maximum likelihood method. These patients were treated based on RTOG 1112 dose prescription protocol. The TCP/NTCP model was used to derive the theoretical maximum therapeutic gain as a function of T/N ratio (tumour mean dose to normal liver mean dose ratio). A new concept, therapeutic efficiency, was developed to evaluate the effectiveness of SBRT in terms of therapeutic gain. It was defined as the actual therapeutic gain divided by the theoretical maximum therapeutic gain.
Results: The analyses showed that the therapeutic efficiency increased with tumour mean dose and T/N ratio for PWH patients. This showed that there might be room for improvement in the dose prescription of certain treatment plans, especially for cases with relatively low tumour mean dose and T/N ratio.
Conclusion: A new concept, therapeutic efficiency, was introduced and used to evaluate HCC SBRT in Prince of Wales Hospital in terms of therapeutic gain.
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