Program Information
HIFU in Oncology
K Sharma1*, G ter Haar2*, (1) Children's National Medical Center, Washington, DC, (2) The Institute of Cancer Research, London, UK
Presentations
8:30 AM : Towards a Completely Non-Invasive Treatment of Benign As Well As Recurrent or Relapsed Malignant Tumors in Children - K Sharma, Presenting Author8:55 AM : Physics aspects of HIFU clinical trials for cancer treatments - G ter Haar, Presenting Author
TU-B-708-0 (Tuesday, August 1, 2017) 8:30 AM - 9:30 AM Room: 708
Image-guided High-Intensity Focused Ultrasound (HIFU) is gaining traction worldwide for precision thermal ablative treatment of benign and malignant tumors. Although the use of HIFU for the treatment of cancer is still in its infancy, ablation of malignant tumors using ultrasound or MR guided systems are under active investigation in sites such as breast, prostate, brain, bone, liver, kidney, pancreas, and soft tissue.
The first invited talk, “Towards a Completely Non-Invasive Treatment of Benign As Well As Recurrent or Relapsed Malignant Tumors in Children”, will present the safety, feasibility and efficacy of a promising non-invasive treatment of osteoid osteoma with Magnetic Resonance Imaging-guided High Intensity Focused Ultrasound (MR-HIFU), comparing it to the current standard of care radiofrequency ablation (RFA). MR-HIFU ablation is safe and feasible and in terms of clinical response and the metrics used, the two treatments appear similar overall, though MR-HIFU offers the additional benefits of a non-invasive treatment that does not require the use of ionizing radiation. The presentation will also summarize several other ongoing clinical trials of MR-HIFU treatment safety and feasibility in children with recurrent or relapsed malignant tumors. In this setting, the MR-HIFU offers the promise of replacing some traditional surgery and radiation therapy - an advance that would be especially beneficial to growing children and young adults.
The second invited talk, “Physics aspects of HIFU clinical trials for cancer treatments”, will discuss criteria for proper HIFU clinical trial design, as well as two ongoing trials. In order for HIFU to gain more acceptance it is important that more evidence for its efficacy is accrued from properly conducted, well designed, clinical trials. Two such trials are being conducted at the Royal Marsden Hospital, into the palliation of pain arising from bone metastases, and the treatment of recurrent pelvic disease in gynaecological patients, and will be reviewed in terms of physics and clinical aspects.
Learning Objectives:
1. Understanding of the physics aspects of clinical trial design for therapeutic ultrasound.
2. Physics aspects of the conduct of clinical trial design for therapeutic ultrasound.
3. Understanding of clinical applications of HIFU therapy.
Handouts
- 127-35748-424554-127810.pdf (G ter Haar)
- 127-38276-424554-133110.pdf (K Sharma)
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