Program Information

Optical Image-Guided Surgery

B Pogue

A Glaser

M Bradbury

K Farahani

B Pogue¹*, A Glaser²*, M Bradbury³*, (1) Dartmouth College, Hanover, NH, (2) University of Washington, Seattle, WA, (3) Weill Medical College of Cornell University, New York, NY

Presentations

7:30 AM : Optical systems to guide therapy: Surgery, photodynamic & radiation therapy - B Pogue, Presenting Author
8:00 AM : Intraoperative light sheet microscopy - A Glaser, Presenting Author
8:30 AM : Clinical translation of C dots for molecularly targeted treatment of nodal disease and peripheral nerve mapping - M Bradbury, Presenting Author
9:00 AM : Panel Discussion - K Farahani, Presenting Author

WE-AB-FS4-0 (Wednesday, August 2, 2017) 7:30 AM - 9:30 AM Room: Four Seasons 4

The goal of oncologic image-guided surgery is to facilitate minimally invasive surgical procedures, enhance surgical precision, and improve surgical outcomes. The lack of clear surgical vision impacts the ability of the surgeon to accurately and specifically identify the extent of malignancy, microscopic tumor burden, or remnant disease. Optical fluorescence-guided surgery has been emerging as a very useful paradigm for tissue perfusion assessment, using non-targeted indocyanine green and fluorescein. Advances are occurring in development of biologically-targeted optical probes, used to denote areas of tissue metabolism or immunologic function, some incorporating nanotechnologies to enhance delivery to tumor or remnant disease. Additionally, intraoperative fluorescence microscopy is emerging as a companion technology in the operating room, providing rapid, slide-free, non-destructive molecular imaging and pathology of excised tissues.

This symposium will present the state-of-the-art FDA-approved systems and emerging technologies in optical image-guided surgery and microscopy, including multi-spectral systems, enzymatic and receptor targets, nanotechnologies, and quantitative methods. A review of these systems, as well as their advantages and disadvantages in the context of intraoperative imaging will be discussed. Finally, perspectives on the future of the field, the potential clinical impact, and barriers to adoption, and the role of medical physics and bioengineering to support and guide the field as it evolves will be discussed.

Learning Objectives:
1. Understanding basic physical principals and clinical advantages of optical image-guided surgery
2. Understanding current approaches to targeted dyes and quantitative methods
3. Understanding current approaches to optical fluorescence microscopy

Handouts

• 127-35300-418554-127434.pdf (B Pogue)

• 127-35301-418554-127432-530705905.pdf (A Glaser)

• 127-35303-418554-126273.pdf (K Farahani)

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