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Program Information

Joint Scientific Symposium with ESTRO: From Bench to Bedside Via Veterinary Radiation Oncology

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M Kent

S Sapareto

S Dieterich

T Yamamoto





M Kent1*, S Sapareto2*, S Dieterich3*, T Yamamoto4*, (1) University of California Davis, Davis, CA, (2) Banner University Medical Center - Phoenix, Phoenix, AZ, (3) UC Davis Medical Center, Sacramento, CA, (4) UC Davis School of Medicine, Sacramento, CA

Presentations

4:30 PM : The tumor micro-environment in mouse, companion animal and human - M Kent, Presenting Author
4:52 PM : Clinical Trials in veterinary Radiation Oncology - S Sapareto, Presenting Author
5:14 PM : Using the Veterinary Radiation Oncology service as implementation pathway for new clinical technology - S Dieterich, Presenting Author
5:36 PM : Veterinary Trials as Stepping Stone to Human Trials - T Yamamoto, Presenting Author

TU-H-FS1-0 (Tuesday, August 1, 2017) 4:30 PM - 6:00 PM Room: Four Seasons 1


Veterinary Radiation Oncology offers many opportunities for translational research, providing a stepping stone between the bench and the bedside as well as unique research opportunities into cancer biology. The dog with spontaneously arising cancer is becoming an accepted model of human cancer for research. Understanding where the model works well and its limitations are essential for integration of the dog into translational cancer research involving radiation therapy. Dogs, being of a relatively larger size than rodent model systems, also have advantages when working with studies involving radiation therapy, allowing the use of the same imaging devices such as CT, MRI and PET scans as well as conventional linear accelerators for instituting treatment protocols. Limitations include limited reagents for molecular testing, a limited genetic profiling of tumors and the microenvironment, recruitment and increased costs for studies compared to rodent models. While not able to replace rodent models of cancer they can complement them and give one more tool for translational studies in cancer.

Several clinical trials are underway in Veterinary Radiation Oncology which are of relevance to human radiation oncology. After introducing the clinical trial environment, two examples will be presented in this session to highlight the benefit of veterinary work for clinical medical physics.

The first example will discuss the advantages (e.g., flexibility in study designs and interventions) and challenges (e.g., cancer prevalence, costs) in imaging research, e.g. associated with canine clinical single-energy CT pulmonary perfusion imaging. It will also discuss practical considerations for canine trials. The second example will discuss how implementation of new technology such as a commercial EPID in-vivo dosimetry program in Veterinary Oncology first can be used to streamline workflow, clinical implementation and the development of appropriate data analysis parameters.

Learning Objectives:
1. Understanding the dog as model for human cancer, including advantages and limitations.
2. Learn about current and future clinical trials in Veterinary Radiation Oncology
3. Understand how the dog can be used as model for imaging research, with the example of lung imaging.
4. Understand how the clinical environment in Veterinary Radiation Oncology can facilitate and streamline implementation of new physics techniques.


Funding Support, Disclosures, and Conflict of Interest: Please see individual speaker disclosures.

Handouts


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