Program Information
Novel Linearly-Filled Derenzo PET Phantom Design
S Graves1*, B Cox1 , M Farhoud2 , H Valdovinos1 , J Jeffery1 , K Eliceiri1 , T Barnhart1 , R Nickles1 , (1) University of Wisconsin - Madison, (2) SOFIE Biosciences, Culver City, CA,
Presentations
TU-H-206-2 (Tuesday, August 2, 2016) 4:30 PM - 6:00 PM Room: 206
Purpose: To design a linearly-filled Derenzo positron emission tomography (PET) phantom, eliminating the extraneous radioisotope volumes in a conventional reservoir-type design. This activity reduction combined with the elimination of bubbles in smaller phantom channels would significantly reduce personnel dose, radioisotope cost, and would improve image quality by reducing out-of-slice activity scatter.
Methods: A computer-aided design (CAD) was created of a modular Derenzo phantom consisting of three phantom layers with gaskets between the layers. The central piece contains the active pattern volume and channels connecting adjacent rods in a serpentine pattern. The two end-pieces contained an inlet and an outlet for filling purposes. Phantom prototypes were 3D printed on a Viper Si2 stereolithography machine. The two gaskets were fabricated from silicon sheets using a PLS 6.75 laser cutter. Phantoms were held together by pass-through glass-filled nylon bolts and nuts. Phantoms were filled with ⁵²Mn, ⁶⁴Cu, ⁷⁶Br, and ¹²⁴I for testing, and were imaged on a Siemens Inveon MicroPET scanner.
Results: Four phantom prototypes were constructed using male Leur Lock fittings for inlet/outlet ports. 3D printed layers were sanded to ensure proper coupling to the silicon gaskets. The filling volume for each prototype was approximately 2.4 mL. The filling process was found to be rapid, leak-tight, and with minimal back-pressure. PET images were reconstructed by OSEM3D, and axial slices along the phantom pattern length were averaged to provide final images. Image distortion was isotope dependent with ⁵²Mn and ⁶⁴Cu having the least distortion and ¹²⁴I having the most distortion.
Conclusion: These results indicate that the linearly-filled Derenzo design improves on conventional reservoir-type designs by eliminating potential bubbles in small channels and by reducing activity level, radioisotope volume, radioisotope cost, personnel dose, filling time, and out-of-slice activity scatter
Funding Support, Disclosures, and Conflict of Interest: The method described in this abstract has been filed as a patent application to the US Patent and Trade Office by the Wisconsin Alumni Research Foundation (WARF).
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