Program Information
Surface Coating for Prevention of Metallic Seed Migration in Tissues
H Lee1 , W Lee2 , J Park1*, Y Choy2,3 , S Ye1,4 , (1) Program in Biomedical Radiation Sciences, Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, (2) Interdisciplinary Program in Bioengineering, Seoul National University College of Engineering, Seoul, Korea, (3) Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea, (4) Department of Radiation Oncology, Seoul National University Hospital, Seoul, Korea,
Presentations
SU-E-T-717 (Sunday, July 12, 2015) 3:00 PM - 6:00 PM Room: Exhibit Hall
Purpose: In radiotherapy, metallic implants often detach from their deposited sites and migrate to other locations. This undesirable migration could cause inadequate dose coverage for permanent brachytherapy and difficulties in image-guided radiation delivery for patients. To prevent migration of implanted seeds, we propose a potential strategy to use of a biocompatible and tissue-adhesive material called polydopamine.
Methods: In this study, non-radioactive dummy seeds that have the same geometry and composition as commercial I-125 seeds were coated in polydopamine. Using scanning electron microscopy and X-ray photoelectron spectroscopy, the surface of the polydopamine-coated and non-coated seeds was characterized. The detachment stress between the two types of seeds and the tissue was measured. The efficacy of polydopamine-coated seed was investigated through in-vitro migration tests by tracing the seed location after tissue implantation and shaking for given times. The cytotoxicity of the polydopamine coating was also evaluated.
Results: The results of the coating characterization have shown that polydopamine was successfully coated on the surface of the seeds. In the adhesion test, the polydopamine-coated seeds had 2.1-fold greater detachment stress than non-coated seeds. From the in-vitro test, it was determined that the polydopamine-coated seed migrated shorter distances than the non-coated seed. This difference was increased with a greater length of time after implantation.
Conclusion: We suggest that polydopamine coating is an effective technique to prevent migration of implanted seeds, especially for permanent prostate brachytherapy.
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