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Repeated 18F-FDG PET/CTs Based Feature Analysis for the Predication of Anal Cancer Recurrence
J Wang1*, M Chuong1 , K Latifi2 , n saeed2 , S Tan1,3 , W Choi1 , S Hoffe2 , R Shridhar2 , E Moros2 , W Lu1 , (1)University of Maryland Baltimore School of Medicine, Baltimore, MD, (2) Moffitt Cancer Center, Tampa, FL, (3) Huazhong University of Science & Technology , Wuhan
Presentations
SU-E-J-270 (Sunday, July 12, 2015) 3:00 PM - 6:00 PM Room: Exhibit Hall
Purpose: To identify PET/CT based imaging predictors of anal cancer recurrence and evaluate baseline vs. mid-treatment vs. post-treatment PET/CT scans in the tumor recurrence prediction.
Methods: FDG-PET/CT scans were obtained at baseline, during chemoradiotherapy (CRT, mid-treatment), and after CRT (post-treatment) in 17 patients of anal cancer. Four patients had tumor recurrence. For each patient, the mid-treatment and post-treatment scans were respectively aligned to the baseline scan by a rigid registration followed by a deformable registration. PET/CT image features were computed within the manually delineated tumor volume of each scan to characterize the intensity histogram, spatial patterns (texture), and shape of the tumors, as well as the changes of these features resulting from CRT. A total of 335 image features were extracted. An Exact Logistic Regression model was employed to analyze these PET/CT image features in order to identify potential predictors for tumor recurrence.
Results: Eleven potential predictors of cancer recurrence were identified with p < 0.10, including five shape features, five statistical texture features, and one CT intensity histogram feature. Six features were indentified from post-treatment scans, 3 from mid-treatment scans, and 2 from baseline scans. These features indicated that there were differences in shape, intensity, and spatial pattern between tumors with and without recurrence. Recurrent tumors tended to have more compact shape (higher roundness and lower elongation) and larger intensity difference between baseline and follow-up scans, compared to non-recurrent tumors.
Conclusion: PET/CT based anal cancer recurrence predictors were identified. The post-CRT PET/CT is the most important scan for the prediction of cancer recurrence. The baseline and mid-CRT PET/CT also showed value in the prediction and would be more useful for the predication of tumor recurrence in early stage of CRT.
Funding Support, Disclosures, and Conflict of Interest: This work was supported in part by the National Cancer Institute Grant R01CA172638.
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