Program Information
Innovative High-Performance PET Imaging System for Preclinical Imaging and Translational Researches
X Sun1*, K Lou1,2 , Z Deng3 , Y Shao4 , (1) University of Texas MD Anderson Cancer Center, Houston, TX, (2) Rice University, Houston, TX, (3) Tsinghua University, Beijing, China
Presentations
MO-G-17A-1 Monday 4:30PM - 6:00PM Room: 17APurpose:To develop a practical and compact preclinical PET with innovative technologies for substantially improved imaging performance required for the advanced imaging applications.
Methods:Several key components of detector, readout electronics and data acquisition have been developed and evaluated for achieving leapfrogged imaging performance over a prototype animal PET we had developed. The new detector module consists of an 8x8 array of 1.5x1.5x30 mm³ LYSO scintillators with each end coupled to a latest 4x4 array of 3x3 mm² Silicon Photomultipliers (with ~0.2 mm insensitive gap between pixels) through a 2.0 mm thick transparent light spreader. Scintillator surface and reflector/coupling were designed and fabricated to reserve air-gap to achieve higher depth-of-interaction (DOI) resolution and other detector performance. Front-end readout electronics with upgraded 16-ch ASIC was newly developed and tested, so as the compact and high density FPGA based data acquisition and transfer system targeting 10M/s coincidence counting rate with low power consumption. The new detector module performance of energy, timing and DOI resolutions with the data acquisition system were evaluated. Initial Na-22 point source image was acquired with 2 rotating detectors to assess the system imaging capability.
Results:No insensitive gaps at the detector edge and thus it is capable for tiling to a large-scale detector panel. All 64 crystals inside the detector were clearly separated from a flood-source image. Measured energy, timing, and DOI resolutions are around 17%, 2.7 ns and 1.96 mm (mean value). Point source image is acquired successfully without detector/electronics calibration and data correction.
Conclusion:Newly developed advanced detector and readout electronics will be enable achieving targeted scalable and compact PET system in stationary configuration with >15% sensitivity, ~1.3 mm uniform imaging resolution, and fast acquisition counting rate capability for substantially improved imaging and quantification performance for small animal imaging and image-guided radiotherapy applications.
Funding Support, Disclosures, and Conflict of Interest: This work was supported by a research award RP120326 from Cancer Prevention and Research Institute of Texas.
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