Program Information
Uncertainty Analysis for Dose Measurements Using OSLD NanoDots
S Kry*, P Alvarez , F Stingo , D Followill , UT MD Anderson Cancer Center, Houston, TX
Presentations
SU-F-BRE-14 Sunday 4:00PM - 6:00PM Room: Ballroom EPurpose: Optically stimulated luminescent dosimeters (OSLD) are an increasingly popular dosimeter for research and clinical applications. It is also used by the Radiological Physics Center for remote auditing of machine output. In this work we robustly calculated the reproducibility and uncertainty of the OSLD nanoDot.
Methods: For the RPC dose calculation, raw readings are corrected for depletion, element sensitivity, fading, linearity, and energy. System calibration is determined for the experimental OSLD irradiated at different institutions by using OSLD irradiated by the RPC under reference conditions (i.e., standards): 1 Gy in a Cobalt beam. The intra-dot and inter-dot reproducibilities (coefficient of variation) were determined from the history of RPC readings of these standards. The standard deviation of the corrected OSLD signal was then calculated analytically using a recursive formalism that did not rely on the normality assumption of the underlying uncertainties, or on any type of mathematical approximation. This analytical uncertainty was compared to that empirically estimated from >45,000 RPC beam audits.
Results: The intra-dot variability was found to be 0.59%, with only a small variation between readers. Inter-dot variability was found to be 0.85%. The uncertainty in each of the individual correction factors was empirically determined. When the raw counts from each OSLD were adjusted for the appropriate correction factors, the analytically determined coefficient of variation was 1.8% over a range of institutional irradiation conditions that are seen at the RPC. This is reasonably consistent with the empirical observations of the RPC, where the coefficient of variation of the measured beam outputs is 1.6% (photons) and 1.9% (electrons).
Conclusion: OSLD nanoDots provide sufficiently good precision for a wide range of applications, including the RPC remote monitoring program for megavoltage beams.
Funding Support, Disclosures, and Conflict of Interest: This work was supported by PHS grant CA10953 awarded by the NIH (DHHS).
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