Program Information
Physics of MR Imaging to Study Whole Brain Atrophy in Ischemic Stroke Patients
R Konduru1*, S Konduru2 , M Kasam3 , (1) University of Minnesota, Rochester, MN, USA (2) University of Minnesota, Rochester, MN, USA (3) Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Presentations
SU-E-I-44 Sunday 3:00PM - 6:00PM Room: Exhibit HallPurpose:
Studies on Whole brain atrophy (WBA) in ischemic stroke (IS) patients using MRI physics after the onset of stroke symptoms were sporadic in nature. The current work depicts the measurement of atrophy in untreated IS patients using advanced MR Imaging/ processing techniques.
Methods:
We have retrospectively (with approved IRB protocol) collected serial 19 MRI scans of 9 IS patients of age and gender matched with comparable stroke size (30 + 10 cc) admitted in Mayo Clinic from the past five years and have their MRIs between 1 month + 15 days, 6+1 month and 1 year + 1 month after the occurrence of IS. Two MRI exams were also retrospectively collected for 10 healthy subjects (who were not diagnosed with IS symptoms) with a time interval of 1 year + 1 month. The MR follow-up exams were collected on a 3-Tesla GE or Siemens MRI scanner using a matched MRI protocol which consists of T1 imaging sequence for anatomical volume extraction purposes. The images were post-processed using Analyze 11.0 software to calculate whole brain volumes.
The T1/T2 images were processed using Analyze 11.0 software (Biomedical Imaging Resource, Mayo Clinic, Rochester, MN) and volumes were computed in a semi-automated method. For each patient, atrophy is computed at the second data point which is a ratio of change in volume to the original volume.
Results and conclusion:
Compared to the healthy subjects, an increase of 18+10% of whole brain atrophy was observed in IS patients. This may be attributed to the fact that IS patients may suffer increase of atrophy or loss of brain volume compared to the healthy subjects. Additional data is needed to investigate further.
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