Program Information

A New Variable for Plan Quality Evaluation Based On Normal Tissue Sparing

Q Zhang

Q Zhang*, Y Lei , D Zheng , B Morgan , J Driewer , M Zhang , S Li , S Zhou , W Zhen , R Thompson , C Lin , A Wahl , C Enke , University of Nebraska Medical Center, Omaha, NE

Presentations

SU-E-J-13 Sunday 3:00PM - 6:00PM Room: Exhibit Hall

Purpose:The dose dropping speed (DDS) in normal tissue was proposed to assess plan quality. It was tested in stereotactic radiosurgery (SRS) cases.

Methods:The DDS was tested with a total 40 plans for 8 SRS cases. Dynamic conformal arc plans were generated for each case, with prescription dose to isodose levels (IDL) ranging from 50% to 90% with 10% increment to cover the PTV. Forty non-overlapping rind structures of 1mm thickness were created layer by layer from each PTV surface. The average dose in each rind was calculated and fitted with a double exponential function (DEF) of the distance from the PTV surface, which models the steep and moderate portions of the average dose curve in normal tissue. The parameter charactering the steep portion of the average dose curve in the DEF quantifies the DDS in the normal tissue receiving high dose. Provided that the prescription dose covers the whole PTV, a greater DDS indicates better normal tissue sparing.

Results:Among all plans, the DDS was found to be the smallest for prescription of 90% IDL and reached a higher plateau region for prescription to 60% or 70%. The ratio of the highest slope to that of 90% prescription was 1.68±0.35. Analyzed with ANOVA, the DDS difference between the plans with prescription to 60% or 70% IDLS and those with prescription to 90% IDL were found significant (p<0.01). This can be attributed to the field size and penumbra slope change with different prescription levels. The trend became less pronounced with increasing PTV size due to less change of field profile for larger field size.

Conclusion:A method was proposed to estimate dose dropping speed as a measure of plan quality. Based on this measure, prescriptions to 60% and 70% IDLs were found to provide best normal tissue sparing.


Contact Email: