Program Information
A Feasibility Study of Navigation Based Multi Criteria Optimization for Advanced Cervical Cancer IMRT Planning
C Ma*, Shandong Cancer Hospital, Jinan, Shandong
Presentations
SU-E-T-617 Sunday 3:00PM - 6:00PM Room: Exhibit HallPurpose:
This study aims to validate multi-criteria optimization (MCO) against standard intensity modulated radiation therapy (IMRT) optimization for advanced cervical cancer in RayStation (v2.4, RaySearch Laboratories, Sweden).
Methods:
10 advanced cervical cancer patients IMRT plans were randomly selected, these plans were designed with step and shoot optimization, new plans were then designed with MCO based on these plans ,while keeping optimization conditions unchanged,comparison was made between both kinds of plans including the dose volume histogram parameters of PTV and OAR,and were analysed by pairing-t test.
Results:
We normalize the plan so that 95% volume of PTV achieved the prescribed dose(50Gy). The volume of radiation 10, 20, 30, and 40 Gy of the rectum were reduced by 14.7%,26.8%,21.1%,10.5% respectively(P≥0.05). The mean dose of rectum were reduced by 7.2Gy(P≤0.05). There were no significant differences for the dosimetric parameters for the bladder.
Conclusion:
In comparision with standard IMRT optimization, MCO reduces the dose of organs at risk with the same PTV coverage,but the result needs further clinical evalution.
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