Program Information
A Sr-90 Irradiation Device for the Study of Cutaneous Radiation Injury
JE Dorand1,3*, LR Burnett4 , M Tytell2 , JD Bourland1,3, Departments of (1) Radiation Oncology and (2) Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC, 27105, USA (3) Department of Physics, Wake Forest University, Winston-Salem, NC, 27106, USA (4) KeraNetics, LLC, Winston-Salem, NC, 27101, USA
Presentations
WE-D-BRE-1 Wednesday 11:00AM - 12:15PM Room: Ballroom EPurpose: To determine dosimetric character for a custom-built Sr-90 beta irradiator designed for the study of Cutaneous Radiation Injury (CRI) in a porcine animal model. In the event of a radiological accident or terrorist event, Sr-90, a fission by-product, will likely be produced. CRI is a main concern due to the low energy and superficial penetration in tissue of beta particles from Sr-90. Seven 100 mCi plaque Sr-90 radiation sources within a custom-built irradiation device create a 40 mm diameter region of radiation-induced skin injury as part of a larger project to study the efficacy of a topical keratin-based product in CRI healing.
Methods: A custom-built mobile irradiation device was designed and implemented for in vivo irradiations. Gafchromicâ„¢ EBT3 radiochromic film and a PTW Markus chamber type 23343 were utilized for dosimetric characterization of the beta fluence at the surface produced by this device. Films were used to assess 2-dimensional dose distribution and percent depth dose characteristics of the radiation field. Ion chamber measurements provided dose rate data within the field.
Results: The radiation field produced by the irradiation device is homogeneous with high uniformity (~5%) and symmetry (~3%) with a steep dose fall-off with depth from the surface. Dose rates were determined to be 3.8 Gy/min and 3.3 Gy/min for film and ion chamber measurements, respectively. A dose rate of 3.4 Gy/min was used to calculate irradiation times for in vivo irradiations.
Conclusion: The custom-built irradiation device enables the use of seven Sr-90 beta sources in an array to deliver a 40 mm diameter area of homogeneous skin dose with a dose rate that is useful for research purposes and clinically relevant for the induction of CRI. Doses of 36 and 42 Gy successfully produce Grade III CRI and are used in the study of the efficacy of KeraStatâ„¢.
Funding Support, Disclosures, and Conflict of Interest: This project has been funded in whole or in part with Federal funds from the Biomedical Advanced Research and Development Authority, Office of the Assistant Secretary for Preparedness and Response, Office of the Secretary, Department of Health and Human Services, under Contract No. HHSO100201200007C.
Contact Email: