Program Information
A New Approach To Cancer Treatment
S Akber1*, (1) Radiological Physicist, Lorain, OH
Presentations
SU-E-T-18 Sunday 3:00PM - 6:00PM Room: Exhibit HallPurpose: To assess the correlation between mean lethal radiation doses (Do) with NMR water proton spin lattice relaxation time (T1) in different phases of Hela cells.
Methods: Analysis of T1 with Do was assessed in M, G1, G2 and S-phase at energies of 220 kVp, 280 kVp and 1.25 MeV (Co-60).
Results: T1 against Do in M, G1, G2, and S phase at 220 kVp yield a correlation of 0.80. At 280 kVp and 1.25 MeV the correlation is 0.77 and 0.82 respectively.
Conclusion: It appears that T1 value decreases from M phase (1020 ± 84 ms) to S phase (534 ± 43 ms). The Do values increases from M phase to S phase. The variation in T1 and Do in different phases of the cell cycles provide a clue to time the mitotic phase at the radiation treatment time.
It appears that T1 value decreases from M phase (1020 ± 84 ms) to S phase (534 ± 43 ms). The Do values increases from M phase to S phase. The variation in T1 and Do in different phases of the cell cycles provide a clue to time the mitotic phase at the radiation treatment time.
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